Redefining performance in GC-MS

The power of multi-award-winning Orbitrap GC-MS technology has so far allowed scientists to break new ground in gain a broader and deeper understanding of their samples through the use of high-resolution, accurate-mass (HRAM) analysis. An unprecedented level of quantitative and qualitative GC-MS performance can be realized easily and routinely with Orbitrap GC-MS, covering all of your GC-MS requirements needs in your research or routine laboratory -- from targeted quantitation, and broad scope screening through to compound discovery workflows.

Thermo Scientific Exactive™ GC Orbitrap™ GC-MS and Q Exactive GC Orbitrap™ GC-MS/MS systems allow you to go beyond what’s possible in your laboratory today and allow you to redefine performance in GC-MS analysis.

Technology Q Exactive GC System Exactive GC System The Analytical Scientist


Unprecedented Depth in GC-MS Analysis

A comprehensive understanding of samples has been out of reach for GC-MS users for too long. The Thermo Scientific Q Exactive GC Orbitrap GC-MS/MS system and the new Thermo Scientific Exactive GC Orbitrap GC-MS system have changed all of that.

Both systems allow scientists working in fields such as food safety, environmental, industrial, forensics and anti-doping to revolutionize their workflows by taking their analytical capability to the next level.



A New Chapter in GC-MS: Beyond a Limited Past

Today, the Q Exactive GC system makes this comprehensive analysis a reality. It is an easy-to-use, dedicated benchtop GC-MS system that provides the highest confidence in compound discovery, identification and quantitation for a comprehensive understanding of your samples. This performance is achieved through the superior resolving power, mass accuracy and sensitivity that only Thermo Scientific™ Orbitrap™ technology can deliver.

The capabilities of the Q Exactive GC system create a paradigm shift for analysis of GC-amenable compounds and signals the start of an exciting new chapter in GC-MS...



The Frontier of Routine GC-MS

The Exactive GC system is an easy-to-use, dedicated GC-MS that provides an unprecedented level of highly sensitive, routine-grade performance for both targeted and non-targeted analysis, along with high confidence quantitation for the ultimate sample analysis workflow. This is achieved through the superior resolving power, mass accuracy, linear dynamic range and sensitivity that only Orbitrap technology can deliver, combined with the intelligent data processing workflows provided by Thermo Scientific™ TraceFinder™ Software.

Bringing GC and Orbitrap
Technology Together

Click on the dots to learn more about the technology behind the worlds most anticipated GC-MS system

Switch to explore the Exactive GC System

Bringing GC and Orbitrap
Technology Together

Click on the dots to learn more about the technology behind the worlds most anticipated GC-MS system

Switch to explore the Q Exactive GC System

HCD Collision Cell

Higher-energy collisional dissociation for MS/MS characterization of ions-used in combination with chemical ionization to help elucidate chemical structures

C-Trap

Curved linear trap for precise ion injection-delivers excellent in-spectrum dynamic range and ensures outstanding HRAM performance across a wide range of concentrations through automatic gain control (AGC)

Advanced Quadrupole Technology (AQT)

High transmission of selected masses for low-level detection and quantitation of lowabundance compounds in highly complex matrices

Orbitrap Mass Analyzer

Incredible resolving power up to 120,000 FWHM for the Q Exactive GC at m/z 200 and up to 50,000 FWHM for the Exactive GC at m/z 272, sub-ppm mass accuracy with a high acquisition rate, driving unrivaled spectral quality.

Mass calibration of the Orbitrap Analyzer is extremely fast and complete within 30s. The resulting calibration is stable for many days under normal condisions.

* videos recorded on Q Exactive GC

Every single scan taken using an Orbitrap mass analyzer is accurate and acquisitons rates are fast enough even for narrow GC peaks that are 1-2s wide.

* videos recorded on Q Exactive GC

Switching between resolving powers on the Orbitrap mass analyzer does not significantly compromise sensitivity.

* videos recorded on Q Exactive GC

Bent Flatapole

For lowest possible noise and maximum robustness

Thermo Scientific™ ExtractaBrite™ Ion Source

Robust, rugged electron impact (EI) and chemical ionization (CI) performance - proven in routine applications in the Thermo Scientific™ ISQ™ and TSQ 8000 series GC-MS systems. Fully removable without breaking vacuum for maintenance or switching to chemical ionization (CI). Also exchangeable for a unique source plug, making GC columns easily exchanged, without venting the MS system.

The Q Exactive GC system source tuning is incredibly fast. The process is complete in ~ 30s.

Rich Whitworth

I’m Rich Whitworth, Editor of The Analytical Scientist. I've been given the exciting opportunity to speak at length with leading experts on the introduction of disruptive new technology: gas chromatography coupled with Orbitrap mass spectrometry. What have I learned? Firstly, that GC-Orbitrap technology has been eagerly anticipated for some time; and secondly, that next generation GC-MS systems will have a resounding impact on diverse application areas, including metabolomics, environmental and food analysis, to name a few. But don't take my word for it. Watch and listen to what Hans Mol, Karl Burgess, Jana Hajšlová - and several other experts - have to say about their first-hand experiences with Orbitrap GC-MS technology.

"GC Orbitrap is clearly a major step forward"

Dr. Hans Mol
RIKILT, Netherlands
Natural Toxins and Pesticides

Article: The Frontier of Gas Chromatography

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"this is the technology platform I have been waiting for since I started in metabolomics"

Dr. Karl Burgess
Glasgow Polyomics
University of Glasgow, UK
Metabolomics

Article: Cutting-Edge Metabolomics

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"GC Orbitrap will bring a new level of performance to high resolution GC-MS"

Prof. Jana Hajšlová
University of Chemical Technology
Prague, Czech Republic
Food Safety and Food Authenticity

Article: Attaining Accurate Authentication

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"the chance to look for unknown substances, that today remain to be discovered, is a real advance in MS"

Dr. Esteban Abad Holgado
Spanish Council for Scientific Research
Barcelona, Spain
Dioxins and POPs & Emerging compounds

Analytical Scientist: Next Generation GC-MS with Alexander Makarov

Alexander Makarov, Director,
Global Research Life Science Mass Spectrometry,
Thermo Fisher Scientific, Germany.

Article: Orbitrap™: Ten Years Young

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Analytical Scientist: Next Generation GC-MS with Richard Fussell

Richard Fussell,
Global Marketing Manager - Food and Beverage,
Chromatography and Mass Spectrometry Division,
Thermo Fisher Scientific,

Article: A Taste of the Other Side

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Joshua Coon on the Importance of Orbitrap Technology to GC-MS

Prof. Joshua Coon
Department of Chemistry
University of Wisconsin, USA
Proteomics and Metabolomics

Article: Reinventing GC-MS

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Q Exactive GC Orbitrap GC-MS/MS System

Superior Compound Discovery and Identification

The Q Exactive Orbitrap GC-MS/MS system provides you with the power to discover features within a sample that went unnoticed with previous GC-MS technology. This unrivalled combination of high-resolution gas chromatography separations and highly sensitive HRAM acquisitions and intelligent identification software will help unlock answers to questions about the very nature of each sample you inject.


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A Brief Introduction to the Q Exactive GC System

Thermo Scientific Q Exactive GC Orbitrap GC-MS/MS system has finally arrived. This highly anticipated, high resolution accurate mass (HRAM) GC-MS/MS system has been demanded by scientists around the world working in many different fields ranging from Metabolomics to food safety, industrial to clinical and pharmaceutical analysis.

Until now, GC-MS technology has been limited with respect to the collection of comprehensive qualitative and quantitative sample information with high levels of selectivity, sensitivity and confidence; especially in highly complex samples.

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Discover

High capacity component detection

Part-per-trillion level sensitivity of the Q Exactive GC system in full scan with a wide dynamic range and HRAM drives high capacity component detection, even in your most complex samples.

Full scan acquisition (60, 000 resolution at 200 m/z) of a food packaging sample from an extractables and leachables study. Single, unidentified component visible within the complex matrix background.

Highly resolved components for chemometric analysis and compound identification

In addition to the highest quality raw data, the Q Exactive GC system uses newly developed specialist deconvolution software tools to automatically detect components within your sample and generate clean spectra for further data processing steps.

Co-eluting compounds are deconvoluted to obtain clean mass spectra.

Principle component analysis (PCA) generated using Thermo Scientific™ Compound Discoverer™ 2.0 software from a study profiling single malt whiskies of different age declaration using the Q Exactive GC system.

Identify

Powerful software for intelligent identification

The Q Exactive GC system uses vast, readily available nominal mass electron ionization (EI) libraries (such as NIST and Wiley) to generate candidate compounds. Hits are verified using intelligent exact mass interpretation of the fragmented mass spectrum acquired. Customized HRAM libraries can also be used.

High quality deconvolution of spectra from a Scotch whiskey sample during an authenticity study. Automatic identification of unknown peaks was performed using intelligent identification software.

High confidence confirmation

For further information and/or confirmations of compounds, positive chemical ionization (PCI) can be used to yield molecular ions. These ions can be measured directly in the Orbitrap or after fragmentation in the HCD for further HRAM investigation into the compound structure.

EI, PCI, and PCI - MS/MS spectra (60,000 resolution at m/z 200) of terbuthylazine with fragment structure assignment using Thermo Scientific™ Mass Frontier™ spectral interpretation software.

Exactive GC Orbitrap GC-MS System

The Frontier of Routine GC-MS

The introduction of the Exactive GC Orbitrap GC-MS system brings power into the routine environment for the first time. This system allows scientists working in the fields of food safety, environmental, industrial, forensics and anti-doping to revolutionize their workflows by taking their analytical capability to the next level.

Exactive GC is an easy-to-use, dedicated GC-MS that provides an unprecedented level of highly sensitive routine grade performance for both targeted and non-targeted analysis, along with high confidence quantitation for the ultimate sample analysis workflow. This is achieved through the superior resolving power, mass accuracy, linear dynamic range and sensitivity that only Orbitrap technology can deliver, combined with the intelligent data processing workflows provided by TraceFinder software.


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Ultimate Performance for Targeted Screening and Quantitation

High selectivity full-scan analysis brings new possibilities to the routine environment: ease of analytical set-up, almost unlimited scope, efficient automatic data processing and retrospective data analysis. The Exactive GC system has the quantitative power of a GC triple quadrupole MS combined with the full-scan high-resolution, accurate-mass (HRAM) capability that only Orbitrap GC-MS technology can offer. This combination will change your workflows, forever.

Detect and Identify

Confident low-level detection and identification for high efficiency screening workflows

The Exactive GC system offers routine full-scan operation, possible at 15k, 30k, or 60k resolution (at m/z 200) with sub-1 ppm mass accuracy and full-scan sensitivity down to part-per-trillion concentrations. This capability drives truly powerful broad-scope screening methods for food safety, environmental, anti-doping and many other applications where confident ultra trace-level detection is required in difficult matrices.



Impact of resolving power on the mass accuracy of Pyrimethanil at 10 μg/Kg in leek acquired at different resolutions of 15K, 30K, and 60K. A resolution of 60K is required to resolve the Pyrimethanil ion from the matrix interference to achieve a mass accuracy compatible with the regulatory guidelines of <5ppm.>


100 repeat injections of a tomato extract spiked at 10 μg/Kg shows sensitivity is maintained over the 66 hours of continual operation.



Mass accuracy at the limit of identification (0.5-5 μg/Kg) for 51 pesticides in leek, orange and tomato matrices. The consistent low mass errors provides high confidence in positive identifications.

Quantify

Quantitation capability far beyond that of other HRAM GC-MS systems

Even when using non-targeted full-scan acquisition, the Exactive GC system provides the quantitative capability of a GC triple quadrupole instrument operating in selected reaction monitoring (SRM) mode. Sensitivity (6 orders) are excellent, even in complex matrices. This is an unprecedented level of performance in GC-MS only possible with Orbitrap GC-MS technology.

Instrument detection limit (IDL) of 150 pesticides in mixed vegetable matrix using a GC Orbitrap system (full-scan 60k at m/z 200) and GC-MS/MS system (SRM) with a fast GC separation.*

* Data collected on the Q Exactive GC system. The Exactive GC system provides the same level of performance when operated under the same conditions. Please refer to Exactive GC Specification Sheet (PS10506) and Exactive GC Technical Note (TN10511).

Intelligent Non-Targeted Screening

Automatic compound identification in a non-targeted way was once science fiction. Today, with the Exactive GC system and TraceFinder software, it’s a reality. The sensitivity, selectivity and dynamic range of the Exactive GC system provides an unprecedented level of component coverage in GC-MS, and TraceFinder software intelligently mines data sets using automated software workflows that ultimately identify components within the sample. Data interpretation is available in minutes, instead of weeks, and an entirely new host of new possibilities is unleashed within your laboratory.

Detect and Refine



Part-per-trillion level sensitivity of the Exactive GC system in full-scan, with a wide dynamic range and HRAM drives high capacity component detection, even in your most complex samples. Specially designed algorithms perform spectral deconvolution, and generate high-fidelity spectra for each component detected.

Generate Candidates


Refined mass spectra are then screened against spectral libraries to generate candidate compound lists based upon thresholded library match scores.

Filter and Identify



High-resolution filtering (HRF) algorithm uses accurate-mass information to discriminate againstcandidates based on elemental composition for every ion in the mass spectrum. This provides a high confidence identification of components detected.



Component spectrum from peak at 7.8 minutes is library searchable and matched to multiple candidates in NIST 2014 spectral library.


The list of proposed candidates are filtered based on a combination of search index and HRF to quickly propose an identity with a high degree of confidence. In this example, the list of 35 candidates are sorted based on search index and HRF to tentatively identify the compound as benzoic acid, methyl ester.



High-resolution filtering (HRF) algorithm uses accurate-mass information to discriminate againstcandidates based on elemental composition for every ion in the mass spectrum. This provides a high confidence identification of components detected.





Adjustable scope of analysis

TraceFinder software allows the use of multiple library sources for automatic compound identification and these can be both nominal mass or exact mass. These can be existing spectral libraries that have been developed in-house, commercially available libraries such as NIST or Wiley or official Orbitrap GC-MS libraries. The scope of your non-targeted analysis can be easily adjusted; to narrow the scope: a more restricted library or sub-library can be configured; to broaden the scope: larger libraries or combinations of libraries can be used.

The Performance Gap Just Got Wider

Advancing the Lead

Orbitrap GC-MS is already setting the pace in high resolution-accurate mass (HRAM) GC-MS. An unprecedented level of quantitative and qualitative in full-scan allows users to redefine their analysis. But we're not standing still, new capabilities and features are now available, which means the performance gap just got wider...


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New Performance Features

VeV Electron Ionization Technology

Available for existing and new customers, new Variable electron voltage (VeV) technology enables lower eV settings for Electron Ionization (EI). It is a softer EI technique, that promotes higher mass signals and increases sensitivity for compounds prone to extensive fragmentation.

The key benefits of VeV are:

  • Fully automated for optimum performance: Following the simplicity of Orbitrap GC-MS operation, VeV set-up is very simple and easy with fast, fully automated tuning.
  • Increased sensitivity: Compounded by the unrivalled full-scan sensitivity of Orbitrap, VeV enables enhancement of target ion signals, when comparing with standard 70 eV.
  • Increased confidence in identification: VeV promotes molecular ion and diagnostic high mass signals, important information for compound identification and confirmation.
Learn more

Tracefinder Automated Compound Identification

Thermo Scientific™ TraceFinder™ software features a specialist spectral deconvolution and automated compound ID tool for Orbitrap GC-MS. This tool utilizes high resolution spectral deconvolution, library searching (low resolution and high resolution libraries) and high resolution filtering (HRF) to drill down to high confidence putative identifications. Now with the new addition of Kovats retention index to the scoring algorithm, confidence in compound identification is further improved, especially relating to isomeric compounds.

Orbitrap GC-MS HRAM Metabolomics Library

The Thermo Scientific Orbitrap GC-MS HRAM Metabolomics Library is the first commercially available high resolution accurate mass (HRAM) metabolomics library for electron ionization (EI) GC-MS. When used in combination with powerful Orbitrap GC-MS technology and unique Thermo Scientific software data processing tools , the difficult challenge of metabolite identification in untargeted experiments is easier than ever before.

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Explore Deeper Into the Metabolome

Identify more metabolites

Biology is complex. To decipher these complexities, metabolomics analysis demands sophisticated analytical technologies and advanced software solutions. The Thermo Scientific™ Orbitrap™ GC-MS HRAM Metabolomics Library is the first commercially available high resolution accurate mass (HRAM) for electron ionization (EI) GC-MS. It contains more than >900 retention indexed unique entries from more than 800 metabolites, providing a broad coverage of primary and secondary metabolites (including volatiles) in plants, animals and microbes. When used in combination with powerful Orbitrap GC-MS technology and unique Thermo Scientific software data processing tools, the difficult challenge of metabolite identification in untargeted experiments is easier than ever before.


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Metabolomics Library

The key benefits of VeV are:

  • High resolution, high mass accuracy spectra acquired at 60,000 RP (m/z 200)
  • Spectra refined and curated with elemental composition of each EI fragment verified
  • Kovats retention index for each entry
  • PubChem ID for unique metabolites
  • Can be used in combination with existing unit mass libraries

Automated Metabolite Identification

Automatic compound identification in a non-targeted way was once science fiction. Today, with the Orbitrap™ GC-MS and unique proprietary data mining tools, it’s a reality.

The sensitivity, selectivity and dynamic range of the Orbitrap GC-MS provides an unprecedented level of compound coverage in GC-MS, and intelligently mines data sets using automated software workflows that ultimately identify metabolites within the sample.

Data interpretation is available in minutes, instead of weeks, and an entirely new host of new possibilities is unleashed within your laboratory.

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Transcend the traditional

Step Into Modern Gas Chromatography

Tailor the Thermo Scientific™ TRACE™ 1310 Gas Chromatograph to your needs with its proprietary user-exchangeable Instant Connect injector and detector modules. Swapping modules is easy to do by removing and replacing three screws, accessible from the top of the GC. The entire process takes less than five minutes without requiring specialized service assistance. This modularity enables budget-conscious laboratories to purchase a base-configured GC today, then easily expand their capabilities to accommodate new applications and throughput demands tomorrow.


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Instant Connect Injectors


Instant Connect SSL

The Instant Connect SSL (Split/Splitless) injector features an optimized thermal profile developed to avoid sample discrimination in split and splitless mode, allowing the broadest range of analytes to be accurately injected. Its cool injector head guarantees minimum thermal stress to the septum, therefore reducing bleed and extending septa lifetime. Also available with concurrent backflushing.

Instant Connect - PTV

The Instant Connect PTV (Programmed Temperature Vaporizing) injector combines the "discrimination-free" performance of a cold injector with the robustness of a vaporizing injector. Merging fast heating and cooling performance with the inertness of the injector chamber and large sample capacity, this injector is the ideal choice for trace analysis in dirty matrices and for thermally labile compounds. Also available with concurrent backflushing.

Instant Connect Helium Saver Module

A unique solution to a difficult problem, this proprietary split/splitless injector module greatly reduces helium consumption, by using helium only to supply carrier gas flow to the capillary column, while using nitrogen for all other injection processes, including the septum purge, split, and sample vaporization.


Instant Connect Detectors


Instant Connect-FID

The Instant Connect-FID (Flame Ionization Detector) offers the highest sensitivity and a wide dynamic range with rapid acquisition speed, making it ideal for extremely fast GC applications.

Instant Connect-TCD

The newly-designed micro-volume Instant Connect-TCD (Thermal Conductivity Detector) is used in a wide variety of capillary and packed column applications. Due to its exceptional thermal stability and fast response, this non-destructive detector provides exceptional sensitivity over the widest range of applications.

Instant Connect-ECD

The new Instant Connect-ECD (Electron Capture Detector) is excellently optimized for trace analysis in challenging samples. Its miniaturized cell, equipped with a purged, removable anode, has been designed to guarantee the utmost sensitivity while maximizing robustness towards the matrix effect.

Instant Connect-NPD

Built upon the proven sensitivity of the Thermo Scientific Nitrogen Phosphorous Detectors (NPD), the new Instant Connect-NPD brings exceptional flexibility to the determination of specific components with the adoption of multiple dedicated ion sources.

Instant Connect-FPD

The Instant Connect-FPD (Flame Photometric Detector) provides excellent sensitivity and response stability for the most demanding sulphur applications, as well as phosporous or tin determinations. Its extended operating temperature range and dual wavelength capability further expand its applicability.

Exceptional Retention Time Stability



Retention time stability on 10 consecutive runs of hydrocarbon mix. Retention time standard deviation is always ≤1/1000 minute.

Outstanding retention time stability is achieved, even in the most complex GC and GC-MS applications, through the use of innovative and unique IEC (integrated electronic control) modules. This stability guarantees industry-leading 0.001 psi control through the entire working range. These miniaturized gas controls, integrated within every injector or detector module for compact, self-sufficient fully-featured devices, deliver strictly controlled pressure or flow to columns and detectors. Setting constant or ramped pressures and flows is easy through the software or the local user interface, while the electronic control maintains the stability during every run for exceptional retention time, accuracy, and precision. To further enhance analytical performance, the IEC module also supports the automated leak check of the injector and column installed and column evaluation procedures.



The TRACE 1300 Series GC quickly reaches near-ambient temperatures.

Fast oven temperature cycling and excellent retention time performance mean that high-precison, high-productivity data sets can be realized. This type of data is especially important to facilitate statistics in larger batches, e.g., in "-omics"-type studies with many biological or technical replicates.

A step ahead in automated sampling

A perfect match for the Q Exactive GC system, the Thermo Scientific™ TriPlus™ RSH autosampler utilizes robotic sample handling to expand automated capabilities beyond liquid, headspace, and solid-phase microextraction (SPME) injections to advanced sample handling cycles. Your results benefit from improved precision and reproducibility, while your laboratory gains unique advantages from the system's unattended operations and sample handling flexibility.

  • Automate basic sample and standards preparation procedures such as dilution, internal standard addition, and derivatization.
  • High precison injection from low volumes to maximize your analysis opportunities with your most precious samples
  • Automated toll exchange to switch between different syringes and techniques "on-the-fly"


The TriPlus RSH autosampler provides excellent repeatability with microsamples, down to 5 µL in a vial. This feature is particularly interesting for trace analysis, radioactive samples, or samples requiring expensive internal standards.

"The introduction of the Q Exactive GC system is a game changer in this space."

Prof. Joshua Coon

"This is clearly a major step forward."

Dr. Hans Mol

"GC Orbitrap technology will bring a new level of performance to high resolution GC-MS."

Prof. Jana Hajšlová

"The Q Exactive GC brings highly resolved data that allows for advanced deconvolution providing high quality inputs for downstream contextualization software."

Dr. Karl Burgess

Talk to an expert about the power of multi-award-winning Orbitrap GC-MS technology.

Provide your contact information and we will have one of our experts contact you to answer any questions you may have about the Q Exactive GC Orbitrap GC-MS/MS system or the Exactive GC Orbitrap GC-MS system.

Thank you for your interest

Thermo Fisher Scientific is excited that you are interested in of our GC Orbitrap systems! One of our experts will contact you shortly.

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Talk to an expert about the power of multi-award-winning Orbitrap GC-MS technology.

Provide your contact information and we will have one of our experts contact you to answer any questions you may have about the Q Exactive GC Orbitrap GC-MS/MS system or the Exactive GC Orbitrap GC-MS system.

Thank you for your interest

Thermo Fisher Scientific is excited that you are interested in of our GC Orbitrap systems! One of our experts will contact you shortly.

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Receive a demo of multi-award-winning Orbitrap GC-MS technology.

Want to see these systems in person? Sign up to see how the Q Exactive GC Orbitrap GC-MS/MS system or the Exactive GC Orbitrap GC-MS system can help solve your toughest scientific challenges!

Thank you for your interest

Thermo Fisher Scientific is excited that you are interested in the one of our GC Orbitrap systems! One of our experts will contact you shortly.

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