Technical Library: LC/MS Solutions for Water Analysis

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Application Notes

535: Rapid solution for screening and quantitating targeted and non-targeted pesticides in water using Exactive Orbitrap LC/MS (PDF 1 MB)
The combination of two different extraction columns yielded easy access to a wide range of environmental compounds in one general approach.

508: Quantification of EPA 1694 Pharmaceuticals and Personal Care Products in Water at the ng/L Level Utilizing Online Sample Preparation with LC-MS/MS (PDF 1.25 MB)
The goal of this application note is to demonstrate a progressive approach to analyzing PPCPs in environmental sources of water at the ng/L level with online sample preparation using small volumes of water, thus saving time and reducing the cost of analysis.

494: Analysis of Basic and Acidic Pharmaceutical Products in Drinking Water Using Online Sample Preparation and LC-MS/MS (PDF 386 KB)
Learn how the team at Bergisches Wasser- und Umweltlaborder BTV-GmbH reduced time spent on sample preparation by 95% by implementing online sample preparation.

491: Analysis of Glyphosate and AMPA in Environmental Water by Ion Chromatography Electrospray Tandem Mass Spectrometry (IC-ESI-MS/MS) (PDF 382 KB)
Learn how to develop an ion chromatography-mass spectrometry (IC-MS/MS) method to separate and quantitate glyphosate and AMPA without derivatization or preparation of complex mobile phases.

479: Quantification of Polyphosphonates and Scale Inhibitors in High Ionic Strength Matrix Effluents Using IC-MS/MS (PDF 469 KB)
Learn how to develop a robust IC-MS/MS method for the quantitation of scale and corrosion inhibitors in a high anionic matrix.

478: Analysis of Triazine Herbicides in Drinking Water Using LC-MS/MS and TraceFinder Software (PDF 1.12 MB)
Learn about a new method to quantitate triazines at the sub-ppt level using new TraceFinder software coupled with LC-MS/MS.

466: Detection of Pharmaceuticals, Personal Care Products, and Pesticides in Water Resources by APCI-LC-MS/MS (PDF 1.24 MB)
The University of Montreal developed a simple method for the simultaneous determination of trace levels of compounds from a diverse group of pharmaceuticals, pesticides, and personal care products using SPE and LC-MS/MS.

454: Analysis of Haloacetic Acids in Drinking Water by IC-MS/MS (PDF 637 KB)
The goal of this AppNote is to develop a simple, rapid, and sensitive IC-MS/MS method for analyzing haloacetic acids in water.

437: LC-MS/MS Analysis of Herbicides in Drinking Water at Femtogram Levels Using 20 mL EQuan Direct Injection Techniques (PDF 296 KB)
The goal of this AppNote is to compare different large volume injections using a loading column and an analytical column with two HPLC pumps.

435: Analysis of Sulfonamides in River Water Using EQuan, an Online Concentration Analysis System (PDF 695 KB)
Learn about a new online concentration analysis system to measure sulfonamide antibiotics at low concentrations quickly and accurately.

434: Analysis of Triazine Pesticides in Drinking Water Using LC-MS/MS (EPA Method 536.0) (PDF 162 KB)
This application note demonstrates the analysis of these compounds over the concentration range 0.25 – 5.0 ng/mL (ppb) using the Thermo Scientific TSQ Quantum Access™ triple stage quadrupole mass spectrometer and the Thermo Scientific Accela™ HPLC system.

403: Analysis of Chloroacetanilide and Other Acetamide Herbicide Degradates in Drinking Water by LC-MS/MS (PDF 245 KB)
This AppNote demonstrates the analysis of chloroacetanilide and other acetamide herbicide degradates using LCMS/MS with no offline sample preparation.

397: Determination of Sulfonamide Antibiotics in Wastewater by Liquid Chromatography - Tandem Mass Spectrometry (PDF 439 KB)
Learn about a new method for the determination of sulfonamide antibiotics at trace levels in effluent wastewaters.

391: Analysis of Regulated Pesticides in Drinking Water Using Accela and EQuan (PDF 967 KB)
The goal of this AppNote is to demonstrate the use of Fast-HPLC and a large volume injection to analyze sub-ppb concentrations of regulated pesticides in drinking water samples.

372: LC/MS/MS Analysis of Anti-Infectives In Raw and Treated Sewage (PDF 830 KB)
The goal of this AppNote is to quantify several anti-infectives at the lower nanogramper-liter level in raw and treated wastewaters. Secondly, to apply two specific single reaction monitoring mode (SRM) transitions and their peak ratio to avoid the presence of false positives.

354: Online Enrichment HTLC/MS/MS Assay for Multiple Classes of Antibiotics in Environmental Water Sources (PDF 641 KB)
Learn about a new online sample clean-up and pre-concentration method that enables you to reduce sample analysis time from hours to minutes.

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Articles

Are oral contraceptives a significant contributor to the estrogenicity of drinking water?
Environmental Science and Technology, January 1, 2011

Des antidépresseurs dans les poissons du Saint-Laurent
Mise à jour le vendredi, January 21, 2011

Blackwell on Health: Even the fish are on Prozac
National Post, January 21, 2011

Fleuve Saint-Laurent - Des poissons drogués au Prozac
La Presse canadienne, Actualités sur l'environnement, January 22, 2011

AP Probe Finds Drugs in Drinking Water
Associated Press, March 10, 2011

U.S. Bolsters Chemical Restrictions for Water
New York Times, March 22, 2010

Saving U.S. Water and Sewer Systems Would Be Costly
New York Times, March 14, 2010

Rulings Restrict Clean Water Act, Hampering E.P.A.
New York Times, March 1, 2010

Tap Water Can Be Unhealthy but Still Legal
New York Times, December 16, 2009

Millions in U.S. Drink Contaminated Water, Records Show
New York Times, December 7, 2009

Sewers at Capacity, Waste Poisons Waterways
New York Times, November 23, 2009

Cleansing the Air at the Expense of Waterways
New York Times, October 12, 2009

Health Ills Abound as Farm Runoff Fouls Wells
New York Times, September 17, 2009

Analysis of natural and synthetic estrogenic endocrine disruptors in environmental waters using online preconcentration coupled with LC-APPI-MS/MS
Science Direct, May 17, 2008

On-line solid phase extraction and liquid chromatography/tandem mass spectrometry to quantify pharmaceuticals, pesticides and some metabolites in wastewaters, drinking, and surface waters
Journal of Environmental Monitoring, March 12, 2008

A fully automated on-line preconcentration and liquid chromatography-tandem mass spectrometry method for the analysis of anti-infectives in wastewaters
Science Direct, October 9, 2007

Determination of six anti-infectives in wastewater using tandem solid-phase extraction and liquid chromatography-tandem mass spectrometry
Jounal of Environmental Monitoring, March 13, 2007

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Case Studies

Eawag, Swiss Federal Institute of Aquatic Science and Technology: Study of Antibiotics and Pesticides in Water Using Automated, Online SPE-LC-MS/MS (PDF 643 KB)
Learn how one lab used automated LC-MS to conduct mass flow studies to determine the occurrence and fate of antibiotics and pesticides in the aquatic environment.

Henri Tudor and the Luxembourg Water Management Administration: Environmental Quantitation System Lowers Costs and Increases Throughput (PDF 638 KB)
The Luxembourg-based Public Research Centre Henri Tudor and the Luxembourg Water Management Administration (WMA), recently completed an extensive two-year, 800-sample study of potential chemical contamination of Luxembourg's aquifers.

Laboratoire Départemental de l'Eau de la Haute-Garonne, France: Pesticides and Herbicides in Groundwater Using Automated, Online SPE-LC-MS/MS (PDF 356 KB)
Learn how a respected lab in France implemented automated LC-MS technology to increase throughput and improve LODs.

Environmental Analytical Chemistry Laboratory at the University of Montreal: LC-MS/MS Online Sample Preparation for Water Analysis (PDF 375 KB)
Learn how one of Canada's major Universities improved limits of detection (LODs) by 100x and reduced sample preparation to about 15 minutes.

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Posters

Multi-residue analysis of pharmaceuticals by on-line preconcentration LC-MS/MS in water samples (PDF 473 KB)

Quantitation of Organophosphate Insecticides in Drinking Water Using Automated Online Sample Prep and Ion Trap (PDF 905 KB)

Screening for PPCPs in Drinking Water Using 3-D Ion Trap and Automated Online Sample Preparation (PDF 309 KB)

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Webinars

Target and non-target analyte screening in natural water samples using Orbitrap by Heinz Singer, Eawag: Swiss Federal Institute of Aquatic Science and Technology Part 1 of 2 (18 mins), Part 2 of 2 (11 mins)
Learn how high resolution accurate mass systems compare to triple stage quadrupole systems when screening for both target and non-target analytes in water.

EQuan System for Groundwater Analysis in Luxembourg by Luc Zwank, Ph.D., Centre de Ressources des Technollogies pour l'Environnement (21 mins)
Learn about the development, validation and routine application of Thermo Scientific EQuan sample preparation technique coupled to HPLC-MS/MS.

Introduction to the QED Scan Function for Triple Quadrupole Mass Spectrometry by Jonathan Beck, Ph.D., Thermo Fisher Scientific (18 mins)
Learn how the quantitation-enhanced data dependent (QED) scan function enables the collection of both qualitative full-scan Q3 data and quantitative selective reaction monitoring (SRM) data in the same experiment - and how to apply QED to any workflow, from proteomics to drug metabolites to environmental contaminants.

Pharmaceuticals and Personal Care Products in Water by Sébastien Sauvé, Ph.D., Department of Chemistry, University of Montreal (60 mins)
Learn about pharmaceuticals in the environment, how to detect and measure for them, and how to reduce exposure and risks.

EQuan System for Environmental and Drinking Water Analysis by Jonathan Beck, Ph.D., Thermo Fisher Scientific (29 mins)
Learn how Thermo Scientific EQuan environmental quantitation system reduces analysis time - from days to minutes - while still providing the sensitivity and specificity you require. The webinar includes real-life customer data.

What Bottlenecks are Slowing Down Your Lab? Learn About Software Solutions for Environmental Testing. by Charles Yang, Thermo Fisher Scientific (26 min)
This webinar explores how current routine environmental lab bottlenecks can be improved by using current TraceFinder* software, EQuanMax* and TSQ* Quantum Ultra to speed up sample through put, as well as data processing and review.

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Videos

Utilizing On-line Pre-concentration with LC/MS/MS for the Quantification of Pharmaceuticals and Personal Care Products in Water at the ng/L Level by Kevin McHale, Thermo Fisher Scientific (21 mins)
Listen to this oral presentation from the 58th ASMS Conference where Kevin McHale discusses using online sample preparation and timed SRMs to increase the performance of the triple stage quadrupole mass spectrometer to analyze PPCPs in water – specifically addressing EPA 1694.

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Resources

Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999 - 2000: A National Reconnaissance

EPA: Drinking Water Contaminant Candidate List

How to Dispose of Unwanted Medications, Florida Department of Environmental Protection

How to Dispose of Household Waste, Florida Department of Environmental Protection

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News & Events

Environmental News

Environmental Events

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Contact Us

Feel welcome to email comments or questions to watersafety@thermo.com.